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Need for customized medication
Last Year 32,000 Ontarians Needed a Lower than Available Dose
The Globe & Mail article reports that last year in Ontario 27% of seniors taking thiazide diuretics
and beta blockers required a lower than commercially available dose.
The need for lower doses of commercially available medications appeared in the academic press as
early as 1991. Writing in the Lancet, Herxheimer noted that some commercially available drugs
may contain as much as 70% more medications than required by the patient.
On average drugs probably contain 25% in excess of that required by the patient.
"Drugs are often introduced at a dose that will be effective in around 90% of the target population,
because this helps market penetration"
The problem becomes critical in the elderly because aging is accompanied by a reduction in cardiac
and renal reserves. In the elderly, physiological adjustments available to the young no longer
function. Thus there is a need for dose titration in order to supply just the correct amount of
medication for a given patient.
Some physicians and patients attempt to solve the problem by cutting tablets in half.
Going from a whole tablet to half a tablet represents a 50% reduction in dosing.
Alternatively going from half a tablet to a whole tablet represents a 100% increase in dosing
The Exact Script ® Compounding Service introduces total dosing flexibility.
With the Exact Script ® Service we can prepare capsules in any strength thereby improving
compliance and therapeutic outcomes.
Medications custom prepared to achieve specific therapeutic goals are reimbursed by most drug plans.
If you would like more in depth information, we would be please to send you a copy of one of the
scientific articles listed below.
References:
1) How much drug in the tablet? Herxheimer, A. Lancet 337:346-348
1991.
2) Age- and Gender-Related use of Low-Dose Drug Therapy: The Need to Manufacture
Low Dose-Dose Therapy and Evaluate the Minimum Effective Dose
Rochon, P.A. et al Journal of the American Geriatrics Society 47:954-959 1999.
Last reviewed/updated: May 1, 2010
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311 Sherbourne St, Toronto, On M5A 3Y1 1-416-960-7768 OCP Accreditation number 17533, owner is Central Medical Pharmacy Inc. Designated manager is Veronique Koo, B Sc Phm. Pharmacists are available for counselling during operating hours.
The information provided on our site is for general information purposes only and is not intended to qualify, supplement or replace that of your medical professional. Your doctor or healthcare giver should undertake diagnosing and treating your medical condition.
[c] © 1999 PurePharm Inc.
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